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Chapter 6 Therapeutic Drug Classes (1 of 10) Sample Questions

1. Which of the following drug classes acts primarily by blocking the conversion of angiotensin I to angiotensin II?

A. Angiotensin-converting enzyme (ACE) inhibitors
B. Angiotensin II receptor blockers (ARBs)
C. Angiotensin II receptor blockers (ARBs)
D. Calcium channel blockers

Ans: A

Tips: ACE inhibitors work by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor. By blocking this conversion, ACE inhibitors reduce vasoconstriction and aldosterone secretion, leading to lowered blood pressure and decreased fluid retention. This class of drugs is commonly used in the treatment of hypertension and heart failure.
• Angiotensin II receptor blockers (ARBs) (option b) block the action of angiotensin II at its receptor but do not inhibit its production.
• Beta-blockers (option c) act by blocking beta-adrenergic receptors, affecting heart rate and contractility, not the renin-angiotensin system.
• Calcium channel blockers (option d) inhibit calcium ions from entering smooth muscle cells, leading to vasodilation, but do not affect angiotensin II formation.

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